Precision Nutrition for Preventing Alzheimer's Disease in ApoE4 Carriers
The ApoE4 allele is the most studied genetic risk factor for Alzheimer's disease, and the incidence of Alzheimer's disease is rising
Explores how to integrate biological age markers—particularly telomere length and epigenetic clocks—into precision nutrition frameworks to achieve personalized interventions, enhance chronic disease management, and promote health
Precision nutrition is gradually emerging as a transformative strategy for optimizing health, especially in biological aging and chronic disease prevention. This explores how to integrate biological age markers—particularly telomere length and epigenetic clocks—into precision nutrition frameworks to achieve personalized interventions, enhance chronic disease management, and promote health. Telomere length is a widely studied biomarker of aging and chronic disease risk, while epigenetic clocks based on DNA methylation patterns provide complementary information about biological age, gene expression, and disease susceptibility. Nutritional interventions rich in antioxidants, omega-3 fatty acids, polyphenols, B vitamins, and anti-inflammatory compounds have shown potential to modulate these biomarkers, thereby supporting cellular health and delaying the aging process. In addition, lifestyle factors such as physical exercise, stress management, and adequate sleep play key roles in maintaining telomere integrity and epigenetic stability.
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